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本文应用放射免疫方法对２５例肝癌、２０例门脉性肝硬化患者的血清透明质酸（ＨＡ）进行了测定，同时用２０例正常人为对照。结果表明：肝硬化及肝癌伴有肝硬化时血清ＨＡ明显增高，与肝癌不伴肝硬化及正常对照组比有显著性差异。ＨＡ的升高与肝硬化的分类有正相关性，肝功损害越重，ＨＡ水平越高。提示ＨＡ对于诊断肝硬化或者临床性肝硬化是较敏感，可靠的指标，同时对于估计肝功储备能力或肝癌切除后的预后也有其重要的临床参考价值。
In this article, serum hyaluronic acid (HA) was measured in 25 cases of liver cancer and 20 cases of portal cirrhosis by radioimmunoassay. At the same time, 20 cases of normal liver were used as controls. The results showed that serum HA was significantly higher in cirrhosis and hepatocellular carcinoma with cirrhosis, and there was a significant difference compared with liver cancer without cirrhosis and normal control group. The elevation of HA is positively correlated with the classification of liver cirrhosis. The heavier the liver damage, the higher the HA level. It suggests that HA is a sensitive and reliable indicator for the diagnosis of cirrhosis or clinical cirrhosis. It also has important clinical reference value for estimating liver function reserve or the prognosis of liver cancer resection.