Liddle综合征于1963年由Liddle等首次报道。其原发缺陷为全身细胞膜对Na~+通透性增大以致出现高血压、低血钾、碱中毒、低肾素和低醛固酮血症。它除醛固酮低外酷似原发性醛固酮增多症,属常染色体显性遗传病,故又名遗传性假性醛固酮增多症,以别于某些药物、肾脏病所致的假性醛固酮增多症。本征罕见,但在低血钾性高血压症侯群中有重要的鉴别意义。 Liddle syndrome was first reported by Liddle et al in 1963. The primary defect of the whole body membrane Na + permeability increases resulting in hypertension, hypokalemia, alkalosis, low renin and hypoproteinemia. In addition to aldosterone it is low outside resembles primary aldosteronism, is an autosomal dominant genetic disease, it is also known as genetic pseudo-aldosteronism, in addition to certain drugs, kidney disease caused by pseudo-aldosteronism. Intrinsic rare, but in the hypokalemic hypertension group has important differentiating significance.