琥珀酰磺胺噻唑的制造,通常均采用琥珀酸酐与磺胺噻唑于干燥有机溶剂中缩合而得,收率为92%左右;所用溶剂的选择则以亲水溶剂为佳。本品的固相缩合,比采用溶剂法缩合好得多。兹略举其优点如下:(1)不用有机溶剂;(2)设备简单,操作容易;(3)安全;(4)收率高,因而成本降低;(5)琥珀酸酐与磺胺噻唑用料比例差额小。 Succinyl sulfathiazole manufacturing, usually succinic anhydride and sulfathiazole condensation in dry organic solvent derived, yield of about 92%; the choice of solvent used hydrophilic solvent is better. This product solid-phase condensation, condensation than the solvent method is much better. The advantages of this product are as follows: (1) no organic solvent; (2) simple equipment and easy operation; (3) safety; (4) high yield and low cost; (5) succinic anhydride and sulfathiazole Small difference.