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活血化淤是治疗血淤证的总则,针对血淤证的病因病机不同,又可采取益气活血,养血活血,行气活血等具体治则。我们以前的工作发现川芎配伍人参(简称川人组),既体现中医益气活血治则,又有较好的药理作用。实验证实川人组可减轻麻醉犬心肌缺血程度,缩小梗塞范围,促进冠脉侧支循环,提高缺血心肌组织内氧分压,缓解离体鼠心的冠脉痉挛,保护缺血心肌。其作用机制与钙拮抗作用有关。本实验从细胞水平观察
Blood circulation is the general rule for the treatment of blood stasis syndrome. The etiology and pathogenesis of blood stasis syndrome are different, but it can also be taken to treat qi and blood circulation, nourishing blood, promoting blood circulation, and promoting qi and blood circulation. Our previous work found that the combination of chuanxiong and ginseng (Chuanren group) not only embodies the principle of Qi-invigorating and blood-activating, but also has good pharmacological effects. Experiments confirmed that the Chuanren group can reduce the myocardial ischemia in anesthetized dogs, narrow the infarct range, promote coronary collateral circulation, increase the oxygen partial pressure in ischemic myocardium, relieve coronary spasm in isolated rat hearts, and protect ischemic myocardium. Its mechanism of action is related to calcium antagonism. The experiment was observed at the cellular level