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观察２８９例单纯高胆固醇血症和１６８例高胆固醇血症合并高甘油三酯血症患者的载脂蛋白（ａｐｏ）Ａ１、Ｂ１００及Ｅ的变化，并与６１９例单纯高甘油三酯血症和１０６例正常人进行比较。结果表明，高胆固醇和高甘油三酯血症患者ａｐｏＡ１、Ｂ１００、Ｅ及高密度脂蛋白胆固醇（ＨＤＬ－ｃ）明显高于正常人，但Ｂ／Ａ１（ａｐｏＢ１００／ａｐｏＡ１）比值增加仅见于高胆固醇血症。作者认为①高脂血症是载脂蛋白代谢紊乱的标志之一；②Ｂ／Ａ１比值比单纯测定ａｐｏＡ１、Ｂ１００值更能反映载脂蛋白代谢紊乱的程度；③高胆固醇血症时ＨＤＬ－ｃ增加；④推论ａｐｏＥ增加与高甘油三酯血症有关，ａｐｏＥ合并Ｂ／Ａ１比值增加与高胆固醇血症有关。
The changes of apolipoproteins A1, B100 and E in 289 patients with hypercholesterolemia and 168 patients with hypercholesterolemia complicated with hypertriglyceridemia were observed and compared with 619 patients with hypertriglyceridemia and 106 normal subjects for comparison. The results showed that apoA1, B100, E and HDL-c in patients with hypercholesteremia and hypertriglyceridemia were significantly higher than those in normal subjects, but the ratio of apoB100 / apoA1 increased only in hypercholesterolemia Blood disorders. The authors believe ① hyperlipidemia is one of the markers of apolipoprotein metabolism disorders; ② B / A1 ratio than the simple determination of apoA1, B100 values reflect the degree of apolipoprotein metabolism disorders; ③ hypercholesterolemia HDL-c increased ; ④ Corollary apoE increased hypertriglyceridemia, apoE combined with B / Al ratio increased hypercholesterolemia.