观察32例(男20,女12,年龄32±6a)癫痫患者眼球震颤出现及消失与苯妥英钠血浓度的关系,发现(1)出现眼球震颤的血药浓度为37±6μg/mL,提示药物过量;(2)眼球震颤出现在眼球偏斜角度的大小与苯妥英钠血浓度有关,浓度越高,角度越小,在≤45°组为48±3μg/mL,在>45°组则为35±5μg/mL;(3)眼球震颤消失时的血药浓度在20μg/mL左右。 To observe the relationship between the presence and disappearance of nystagmus and the plasma concentration of phenytoin in 32 patients (20 males, 12 females, 32 ± 6 years of age) and found that (1) the plasma concentration of nystagmus was 37 ± 6 μg / mL, suggesting that the drug Excess; (2) the size of nystagmus appears in the angle of eyeball and phenytoin sodium blood concentration, the higher the concentration, the smaller the angle, in the 45 ° group of 48 ± 3μg / mL, in the group of> 45 ° 35 ± 5μg / mL; (3) when the disappearance of nystagmus plasma concentration of 20μg / mL or so.