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目的研究不同剂量石英粉尘所致的肺内炎症反应和纤维化病变间可能的联系.方法用不同剂量的石英粉尘染尘后,对1天组和4周组大鼠分别测定其支气管肺泡灌洗液(BALF)中的细胞总数和分类计数,4周组大鼠还测定了BALF细胞中羟脯氨酸量(HOP)、血清铜蓝蛋白含量(CP)和全肺胶原蛋白量,并观察肺组织的病理变化.结果随着染尘剂量增加,1天组大鼠的细胞总数和中性粒细胞数增多,4周组大鼠的细胞总数和各分类计数增多,HOP、CP和全肺胶原蛋白量增加;4周组大鼠的炎症和纤维化各指标间有良好的相关性.结论石英所致的肺内炎症反应可能与矽肺纤维化发生发展有关.“,”Objective To study the relationship between inflammatory reaction and pulmonary fibrosis caused by different doses quartz.Methods Total cells(TC)and its classification in bronchoalveolar lavage fluid(BALF)were counted for the all experimental rats.Besides,the contents of hydroxyproline(HOP)in the cells of BALF,collagen in lung tissues and ceruloplasmin(CP)in plasma were determined 4 weeks later after quartz exposure,the pathological changes in the lun...