多溴联苯(简称 PBB)是一种混合物,主要由六溴联苯、七澳联苯和八溴联苯组成。作者用本实验前从未交配过的雌性 Wistar纯种大鼠,在妊娠后第6到第14天(以阴道涂片发现精子的那天作为妊娠的0天)中的某一天,由灌胃法一次剂量投给含 PBB 混合物的芝麻油。每组大鼠各给予40、200、400或800mg/kg PBB。对照组不经处理或也用灌胃法给予芝麻油。第20天终止妊娠,解剖后,统计胎盘吸收数,胎鼠重量并检查畸形情况。结果表明:低剂量 PBB 不引起畸形,对胎鼠及胎盘的重量也无影响。高剂量 PBB 不但可以引起胎鼠的死亡和畸形,而且能使胎鼠及胎盘的重量显著减轻。产生的畸形主要为腭裂 Polybrominated biphenyls (PBBs) are a mixture of hexabromobiphenyl, hepta-biphenyl and octabromobiphenyl. The authors used one of the female Wistar rats that had never been mated before the experiment, on day 6 to day 14 (0 day of pregnancy on the day when sperm were found on vaginal smears), by gavage One dose is administered to sesame oil containing PBB blend. Each group of rats was given either 40, 200, 400 or 800 mg / kg PBB. Control group untreated or also by intragastric administration of sesame oil. Twenty days after the termination of pregnancy, anatomy, statistical absorption of the placenta, fetal rat weight and check the deformity. The results showed that: low dose PBB does not cause deformity, fetal and placental weight also had no effect. High-dose PBB can not only cause death and deformity of fetal rats, but also significantly reduce the weight of fetal rats and placenta. The resulting deformity is mainly cleft palate