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给某老年人护理院的45位老人服用β-胡萝卜素,维生素B_6,维生素C,维生素E,锌和硒,或者相应的安慰剂作为日常食物的补充,为期一年。开始时,这些老年人的血清脂质过氧化物水平(2.7±0.7μmol/L)高于作为对照组的年轻健康成年人(2.3±0.6μmol/L),P<0.01。服药三个月后,老年人的血清脂质过氧化物已降至2.2±0.6μmol/L,并且保持这一低水平直到研究结束,而服安慰剂者血清脂质过氧化物无变化。 血清脂质过氧化物与全血硒浓度呈显著负相关(r=-0.428,P<0.01),但只有在血硒高于200μg/L时才可见血清脂质过氧化物的降低。血清α-维生素E浓度也与血清脂质过氧化物呈负相关,但相关程度(r=-0.273,P<0.76)低于与血硒间的相关。 从生物化学角度看,25％的老年人可观察到维生素B_6缺乏;每天补充2mg维生素B_6彻底治愈了全部的病例。服药组经几项心理学检验有轻微改善,而服用安慰剂的对照组无变化或者恶化。护士报告在服药组中见有临床改善,未见有毒性副作用。老年人服用抗氧化剂从生物化学和临床上都是有益的。
Forty-five elderly people in an elderly nursing home took beta-carotene, vitamin B_6, vitamin C, vitamin E, zinc and selenium, or their placebo, for one year as supplements to their daily diet. Initially, these elderly individuals had elevated serum lipid peroxidation levels (2.7 ± 0.7 μmol / L) compared with younger healthy adults (2.3 ± 0.6 μmol / L) as a control group, P <0.01. Three months after taking the drug, the elderly’s serum lipid peroxides had dropped to 2.2 ± 0.6 μmol / L and remained low until the study was completed, with no change in serum lipid peroxidation in the placebo. There was a significant negative correlation between serum lipid peroxidation and whole blood selenium concentration (r = -0.428, P <0.01). However, serum lipid peroxidation decreased only when selenium was higher than 200 μg / L. Serum a-tocopherol concentration was also negatively correlated with serum lipid peroxidation, but the correlation (r = -0.273, P <0.76) was lower than that between blood selenium and selenium. Biochemically, vitamin B_6 deficiency is observed in 25% of the elderly; 2 mg of vitamin B_6 is added daily to completely heal all cases. The medication group was slightly improved by several psychometric tests, whereas the placebo-treated control group showed no change or worsened. Nurses report in the medication group to see clinical improvement, no toxic side effects. Taking antioxidants in the elderly is biochemically and clinically beneficial.