AIM To identify and assess the research situation of top 100 cited articles in nonalcoholic fatty liver disease(NAFl D).METHODS The global scientific research articles in the science Citation Index-Expanded relevant to NAFl D were retrieved and listed according to their citation times from the most to the least. The 100 most frequently cited original articles were selected to systematically evaluate their bibliometric parameters including times cited, publication year, journals, subject categories, and the highly related concepts of NAFl D, which reflected the history and current situation, publication distribution of leading countries and institutes as well as the research hotspots of NAFl D.RESULTS Top 100 cited articles in NAFl D were published from 1965 to 2015 with a citation ranging of 227 to 2151 times since publication, in which the United states was the most predominant country and Mayo Clin was the most productive institution. The majority of the top 100 cited articles were concentrated in s CI subject category of Gastroenterology and Hepatology. Hepatology and Gastroenterology is the top journal that published over half 100 top-cited articles. The significant peak of top cited articles present in the first half of the 2000 s while the highest mean number of citation presents in first half of the 1980 s. In addition, concepts related to pathology characteristics, epidemiology and medicalization, metabolic syndrome and its combination of symptoms including insulin resistance, biomarkersof lipid metabolism and obesity are listed as the highly related concepts.CONCLUSION The 100 top-cited articles marked with the leading countries, institutions, journals, hotspots and development trend in NAFl D field that could provide the foundation for further investigations. AIM To identify and assess the research situation of 100 cited articles in nonalcoholic fatty liver disease (NAFID). METHODS The global scientific research articles in the science Citation Index-Expanded relevant to NAFl D were retrieved and listed according to their citation times from the most to the least. The 100 most frequently cited original articles were selected to systematically evaluate their bibliometric parameters including times cited, publication year, journals, subject categories, and the highly related concepts of NAF1 D, which reflected the history and current situation, publication distribution of leading countries and institutes as well as the research hotspots of NAF1 D.RESULTS Top 100 cited articles in NAF1 D were published from 1965 to 2015 with a citation ranging of 227 to 2151 times since publication, in which the United states was the most predominant country and Mayo Clin was the most productive institution. The majority of the top 100 cited articles were c oncentrated in s CI subject category of Gastroenterology and Hepatology. Hepatology and Gastroenterology is the top journal that published over half 100 top-cited articles. The significant peak of top cited articles present in the first half of the 2000 s while the highest mean number of citation presents in first half of the 1980 s. In addition, concepts related to pathology characteristics, epidemiology and medicalization, metabolic syndrome and its combination of symptoms including insulin resistance, biomarkers of lipid metabolism and obesity are listed as the highly relevant concept .CONCLUSION The 100 top-cited articles marked with the leading countries, institutions, journals, hotspots and development trend in NAF1 D field that could provide the foundation for further investigations.