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目的 :探讨乳腺导管原位癌(DCIS)的X线特征及其病理核分级与雌激素受体(ER)、孕激素受体(PR)表达的关系。方法 :选取本院病理科收集的手术切除后经病理学证实的152例DCIS(152个病灶)的术前X线检查结果、术后病理学结果进行回顾性分析,对DCIS病灶的X线特征进行描述分析,分析不同病理学分级DCIS患者与ER、PR表达的相关性。结果 :152个DCIS病灶中,构成比最多的前三位分别是单纯钙化病灶41个(26.97%)、不对称密度钙化灶27个(17.76%)、肿块钙化灶26个(17.11%),共计钙化病灶108个,不定形模糊8个、粗燥不均质8个、细小多形性57个、线样分支状12个、混合性23个;单纯DCIS病灶、DCIS伴浸润性病灶的ER、PR阳性表达率差异均无统计学意义;DCIS病灶中组织学Ⅰ级、Ⅱ级、Ⅲ级的ER、PR阳性表达率差异均具有统计学意义。结论 :DCIS病灶具有较为显著的的X线特征,DCIS组织学分级与PR、ER表达具有一定的关系。
OBJECTIVE: To investigate the X-ray features of breast ductal carcinoma in situ (DCIS) and the relationship between its pathological nuclear grade and the expression of estrogen receptor (ER) and progesterone receptor (PR). Methods: The preoperative X-ray findings of 152 cases of DCIS (152 lesions) confirmed by pathology collected after surgical resection in our hospital were retrospectively analyzed. The X-ray features of DCIS lesion Descriptive analysis was performed to analyze the correlation between the expression of ER and PR in patients with different pathological grades of DCIS. Results: Among the 152 DCIS lesions, the top three most common lesions were 41 (26.97%) with calcified lesions, 27 (17.76%) with asymptomatic calcifications and 26 (17.11%) with calcified lesions There were 108 calcified lesions, 8 indefinitely shaped, 8 rough and heterogeneous, 57 small and pleomorphic, 12 linear mixed and 23 mixed; simple DCIS lesions, DCIS with invasive lesions of ER, PR positive expression rate was no significant difference; DCIS lesions histological grade Ⅰ, Ⅱ, Ⅲ grade ER, PR positive expression rate differences were statistically significant. Conclusion: The DCIS lesion has significant X-ray features. The histological grade of DCIS is related to the expression of PR and ER.