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目的:以脱氢卡维丁为指标成分研究岩黄连总生物碱在大鼠胃、肠的吸收动力学特征。方法:采用大鼠在体胃、肠吸收模型,以高效液相色谱法测定胃、肠灌注液中药物的含量。结果:药物在胃和小肠中的每小时吸收百分率分别为8.88%,2.08%;药物在大鼠十二指肠、空肠的吸收速率常数略高于回肠和结肠部位,但无显著性差异;药物中、高浓度的吸收速率常数基本一致,低浓度的吸收速率常数明显降低;随灌流液pH升高,药物吸收速率常数增大,但也无显著性差异。结论:药物在胃、全肠道均有吸收,但吸收均较差,胃中高于小肠中;不同肠段和灌流液不同pH对吸收无显著性影响;中、高浓度范围内表现为被动扩散吸收机制。
OBJECTIVE: To study the absorption kinetics of total alkaloids from Rhizoma Coptidis in the stomach and intestine of rats by using dehydrocavitine as an index component. Methods: Rat stomach and intestine absorption model was used to determine the contents of drugs in gastric and intestinal perfusate by high performance liquid chromatography. Results: The hourly absorption rates of drugs in the stomach and small intestine were 8.88% and 2.08%, respectively. The absorption rate constant of drugs in the duodenum and jejunum of rats was slightly higher than that in the ileum and colon but no significant difference. The drug The absorption rate constants of medium and high concentrations were basically the same, and the absorption rate constants of low concentration were significantly decreased. With the increase of pH, the absorption rate constant increased, but there was no significant difference. Conclusion: The drug is absorbed in the stomach and the intestine, but the absorption is poor, the stomach is higher than the small intestine; different intestinal segments and perfusate different pH had no significant effect on absorption; medium and high concentration range showed passive diffusion Absorption mechanism.