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为探讨慢性肥厚性鼻炎发病机理，本文对慢性肥厚性和慢性单纯性鼻炎鼻甲标本中肥大细胞，成纤维细胞进行了光镜观察、定量分析及对肥厚性鼻炎标本中的肥大细胞进行了超微结构观察。肥厚性鼻炎１６例，单纯性鼻炎１２例，分别用ＨＥ和甲苯胺兰染色，发现肥大细胞多分布于固有层，肥厚性鼻炎中均数为９７５±１１８，单纯性鼻炎为４８５±１３２，二者有显著差异（Ｐ＜００１）。成纤维细胞数，前者为２３７３±２７８，后者为１４０６±２４３，亦有显著差异。电镜下肥大细胞多数呈活化状态，胞质颗粒大小电子密度不一。
In order to explore the pathogenesis of chronic hypertrophic rhinitis, the paper mast cells and fibroblasts in chronic hypertrophic and chronic simple rhinitis were observed by light microscopy, quantitative analysis and hypertrophy of hypertrophic rhinitis specimens were ultramicro Structure observation. 16 cases of hypertrophic rhinitis, 12 cases of simple rhinitis, respectively, HE and toluidine blue staining and found that mast cells are located in the lamina propria, hypertrophic rhinitis mean 975 ± 118, simple rhinitis is 4 85 ± 1 32, both significant differences (P <0 01). The number of fibroblasts, the former was 23 73 ± 2 78, the latter was 14 06 2 43, also significant differences. Most of mast cells under electron microscopy showed an activated state, cytoplasmic particles of different electron density.