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目的:探讨EB病毒(EBV)DNA载量及EA(早期抗原)IgG抗体滴度与鼻咽癌的临床关系。方法:以2014-05-2015-05共164例入住武汉协和医院肿瘤中心的鼻咽癌患者为研究对象,其中随机做了外周血EBVDNA病毒载量的为89例,89例中随机又检测EA IgG滴度的为51例,结合鼻咽癌的临床分期进行综合分析。结果:在鼻咽癌的临床初级中级阶段(如T1,N0,M0,Ⅰ),EBV-DNA-初诊阴性组的比例大于初诊阳性组(P<0.05)。在整个鼻咽癌诊疗过程中,EBV-DNA的载量呈现波动性下降趋势。EA IgG与放射标准摄取值(SUV)呈现正相关(P<0.05)。EA IgG的滴度随着临床分级的提升而增高,且差异有统计学意义(P<0.05)。结论:在鼻咽癌的临床初级中级阶段,EBV-DNA的病毒载量检测能提高诊断的准确性,在整个鼻咽癌诊疗过程中,EBVDNA病毒载量的波动性及EA IgG抗体滴度与临床分级/放射标准摄取值的一致性能够指导鼻咽癌的治疗。
Objective: To investigate the clinical relationship between DNA load of Epstein-Barr virus (EBV) and IgG titer of EA (early antigen) and nasopharyngeal carcinoma. Methods: A total of 164 nasopharyngeal carcinoma patients from Peking Union Medical College Hospital from 2014-05-2015-05 were enrolled. Among them, 89 cases were randomly divided into EBVDNA viral load in peripheral blood and 89 cases were randomized to detect EA IgG titers for 51 cases, combined with the clinical stage of nasopharyngeal carcinoma for a comprehensive analysis. Results: The proportion of newly diagnosed EBV-DNA-negative group was higher than that of the newly diagnosed group (P <0.05) in the primary stage of NPC (such as T1, N0, M0, Ⅰ) In the whole process of nasopharyngeal carcinoma treatment, EBV-DNA load showed a downward trend in volatility. There was a positive correlation between EA IgG and radioactive standard intake (SUV) (P <0.05). The titer of EA IgG increased with the clinical grade, and the difference was statistically significant (P <0.05). Conclusion: The detection of EBV-DNA viral load can improve the accuracy of diagnosis in nasopharyngeal carcinoma in the clinical primary stage. During the entire course of nasopharyngeal carcinoma treatment, the volatility of EBV DNA viral load and the titer of EA IgG antibody were correlated with Consistency of clinical staging / radiologic standard ingestion can guide the treatment of nasopharyngeal cancer.