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自1922年 Widal 等记录有荨麻疹、重型哮喘、反复发生的鼻息肉及对阿司匹林和安替比林不能耐受的青年女患者以来,已报告的病例颇多,被称为哮喘三联征、Widal 综合征或阿司匹林病等。观察发现,人群中对阿司匹林过敏(HA)者约占0.2％,哮喘患者中更常见,约占10%。凡伴有 HA 的哮喘患者,同时还伴有鼻息肉(ΠH)者占21～50～71％。Abrishami 等综合统计在1327例 HA 患者中,1094例伴哮喘,508例伴有ΠH。哮喘三联征(AT)常见于中年人,儿童亦可见,儿童患者的哮喘出现较晚,平均11岁,且女孩较多。成年患者亦大多为女性,哮喘多属重
Since Widal et al documented cases of hives, heavy asthma, recurrent nasal polyps, and young female patients intolerant to aspirin and antipyrine in 1922, there have been a number of reported cases of asthma triad, Widal Syndrome or aspirin disease. Observations showed that about 0.2% of people in the population were allergic to aspirin (HA), and 10% were more common in asthmatics. Where accompanied by HA asthma patients, also accompanied by nasal polyps (Π H) accounted for 21 to 50 to 71%. Abrishami other comprehensive statistics in 1327 patients with HA, 1094 with asthma, 508 with ΠH. Asthma triad (AT) is common in middle-aged people, children can be seen, children with asthma later, with an average of 11 years old, and girls more. Most adult patients are also women, mostly asthma