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目的探讨血清中免疫球蛋白检验在乙型肝炎(乙肝)诊治中的临床意义,旨在为临床治疗提供更多的参考数据。方法 122例乙型肝炎患者,其中61例慢性重型乙型肝炎患者作为A组,61例慢性乙型肝炎患者作为B组,选取同期61例健康体检者作为C组,对三组的免疫球蛋白(Ig G、Ig A、Ig M)水平、血清总胆红素(TBIL)、凝血酶原时间(PT)进行比较分析。结果 A、B组的Ig G、Ig M、Ig A水平明显高于C组,且A组的Ig G、Ig A、Ig M及TBIL水平显著高于B组,同时PT值明显低于B组,差异均有统计学意义(P<0.05)。结论血清中免疫球蛋白是乙型肝炎临床诊治中的重要指标,其可直接反映出乙肝患者肝细胞受损的程度。因此,临床血清免疫球蛋白的检测对乙肝患者肝功能损害的程度和判断预后具有重要的意义。
Objective To investigate the clinical significance of serum immunoglobulin test in the diagnosis and treatment of hepatitis B (hepatitis B), and to provide more reference data for clinical treatment. Methods A total of 122 patients with hepatitis B were enrolled. 61 patients with chronic severe hepatitis B as group A and 61 patients with chronic hepatitis B as group B, 61 healthy subjects were selected as group C. The immunoglobulin (Ig G, Ig A, Ig M) levels, serum total bilirubin (TBIL), prothrombin time (PT) were analyzed. Results The levels of Ig G, Ig M and Ig A in group A and group B were significantly higher than those in group C, and the levels of Ig G, Ig A, Ig M and TBIL in group A were significantly higher than those in group B, and the PT values were significantly lower than those in group B , The differences were statistically significant (P <0.05). Conclusion Serum immunoglobulin is an important indicator in the clinical diagnosis and treatment of hepatitis B, which directly reflects the degree of liver cell damage in patients with hepatitis B. Therefore, clinical serum immunoglobulin detection of hepatitis B patients with liver damage and determine the degree of prognosis of great significance.