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采用聚合酶链反应结合顺序特异的寡核苷酸（ＰＣＲ／ＳＳＯ）探针杂交方法对ＨＬＡ－ＤＲ、ＤＱ亚区作ＤＮＡ分型，分析了系统性红斑狼疮（ＳＬＥ）的各种临床特征与ＨＬＡ－ＤＲ、ＤＱ基因的关联。结果发现汉族ＳＬＥ中肾脏损害与ＤＲ２相关，而与ＤＲ４呈负相关。口、鼻腔粘膜溃疡与ＤＲ１２相关，未发现ＳＬＥ的其他临床特征与ＤＲ、ＤＱ基因有关。发病年龄小于３５ａ者，ＤＲ２、ＤＱ６阳性率高，而ＤＲ３则多见于发病年龄大于３５ａ者。提示对ＤＲ２阳性及发病年龄小于３５ａ的ＳＬＥ患者要谨防肾脏损害的发生，而ＤＲ４则对肾脏损害的发生有一定的保护性。
The genotypes of HLA-DR and DQ subtypes were genotyped by polymerase chain reaction (PCR) combined with sequence-specific oligonucleotide (PCR / SSO) probe hybridization and the clinical features of systemic lupus erythematosus HLA-DR, DQ gene association. The results showed that kidney damage in SLE was associated with DR2 and negatively correlated with DR4. Oral and nasal mucosal ulcers associated with DR12, did not find other clinical features of SLE and DR, DQ genes. The age of onset less than 35a, DR2, DQ6 positive rate, while the DR3 is more common in patients with age greater than 35a. Prompted for DR2 positive and less than 35a in patients with onset of SLE patients to guard against the occurrence of kidney damage, while DR4 on the occurrence of renal damage have some protection.