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目的:研究冠脉通胶囊对大鼠实验性血栓的影响。方法:取60只SPF级Wistar大鼠随机分为模型组、冠脉通胶囊低、中、高剂量组(0.67,1.34,2.68 g.kg-1)、冠心丹参胶囊组(0.24 g.kg-1)、吲哚布芬片组(0.04 g.kg-1),ig给药7 d,末次给药30 min后麻醉剥离颈总动脉,采用直流电刺激法造成血栓模型,结扎血栓两侧,剪下称量血栓质量,统计平均阻塞率。结果:冠脉通胶囊低、中、高剂量组平均阻塞率(40.25%,37.11%,39.05%)与模型组平均阻塞率(50.99%)比明显降低(P<0.05,P<0.05,P<0.01),同时低、中、高剂量组血栓质量(0.001 9,0.001 7,0.001 5 g)与模型组血栓质量(0.002 6 g)比明显减少(P<0.05,P<0.05,P<0.01),并且具有量效关系。结论:冠脉通胶囊具有抵抗血栓生成的作用。
Objective: To study the effect of Guanmaitong capsule on experimental thrombus in rats. Methods: Sixty SPF Wistar rats were randomly divided into model group, coronary artery capsule low, medium and high dose groups (0.67,1.34,2.68 g.kg-1), Guanxin Danshen capsule group (0.24 g.kg -1), indobufen tablet group (0.04 g.kg-1), ig for 7 days. After the last administration for 30 min, the common carotid arteries were dissected and the thrombus model was induced by DC stimulation. Ligation was performed on both sides of the thrombus, Cut the weight of thrombosis, statistics, the average blocking rate. Results: The average blocking rate (40.25%, 37.11%, 39.05%) in the low, middle and high dosage of Guanmaitong Capsules was significantly lower than that in the model group (50.99%) (P <0.05, P <0.05, P < 0.01). Thrombus quality (0.001 9,0.001 7,0.001 5 g) in the low, medium and high dose groups was significantly lower than that in the model group (0.002 6 g) (P <0.05, P <0.05, P <0.01) , And has a dose-effect relationship. Conclusion: Guanmaitong capsule can resist thrombosis.