轮状病毒(RV)是最常见的严重婴儿胃肠炎的病毒病原体,每年全世界多于800 000婴儿死于此病。RV颗粒由外层衣壳、内层衣壳和包含11个病毒基因组RNA片段的核心3个蛋白层构成。外层衣壳包括糖蛋白VP7和对蛋白酶敏感的VP4 2个蛋白。VP7和VP4在自然感染状况下都能引起中和抗体生成,是病毒最重要的抗原蛋白。在RV血清分型中有两个分类系统,VP7(G型)系统和VP4(P型)系统。对临 Rotavirus (RV) is the most common viral pathogen of severe gastroenteritis in infants and more than 800,000 infants worldwide die each year from the disease. The RV particles consist of the outer capsid, the inner capsid, and the core three protein layers containing 11 viral genomic RNA fragments. The outer capsid includes glycoprotein VP7 and protease-sensitive VP4 2 proteins. VP7 and VP4 in natural infection can cause neutralizing antibody generation, is the virus’s most important antigen protein. There are two classification systems in the RV serotyping, the VP7 (G type) system and the VP4 (P type) system. Right