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目的:了解石家庄市某县健康儿童2010~2012年手足口病病原隐性感染情况。方法:选择赞皇县某乡5岁以下健康儿童,分别于2010年和2012年手足口病流行前、中、后期采集大便标本,用逆转录聚合酶链反应(RT-PCR)进行肠道病毒核酸检测。结果:3年分别观察了59名、89名和77名5岁以下健康儿童,隐性感染率分别为59.32%、47.19%和62.34%。男、女之间的感染率差异无统计学意义(P>0.05);2010年和2011年均显示感染率随着年龄增加而逐渐降低;3年间健康儿童携带的优势病原分别为EV71型(2010年)和其他肠道病毒(2011年、2012年),与赞皇县同期实际监测手足口病病原体不完全相同;不同流行期感染率不同,感染率与同期手足口病患病率变化趋势相同。结论:5岁以下健康儿童肠道病毒带毒较为普遍,系统开展手足口病病原隐性感染状况的调查,有助于手足口病疫情趋势的科学预测。
Objective: To understand the prevalence of HFMD in 2010 ~ 2012 among healthy children in a county of Shijiazhuang. Methods: Stool samples were collected before, during and after HFMD epidemics in 2010 and 2012 in Zhaoxian County, respectively. Stool samples were collected by RT-PCR Nucleic acid test. Results: Fifty-nine, 89 and 77 healthy children under the age of 5 were observed in 3 years. The latent infection rates were 59.32%, 47.19% and 62.34% respectively. There was no significant difference in infection rates between male and female (P> 0.05). In 2010 and 2011, the infection rate decreased gradually with age. The predominant pathogens carried by healthy children in three years were EV71 (2010) Year) and other enteroviruses (2011 and 2012), which are not identical with the actual pathogen of hand-foot-mouth disease monitored by Zanhuang County in the same period. The infection rates at different epidemic stages are different, and the infection rate is the same with that of HFMD over the same period . CONCLUSIONS: Enterovirus infection in healthy children under 5 years of age is more common. Investigation of the status of latent infection of hand-foot-mouth disease pathogens is systematically carried out, contributing to the scientific prediction of the epidemic trend of hand-foot-mouth disease.