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昆明小鼠右后脚垫或右大腿外侧皮下接种肝癌腹水，随机分组。光动力治疗（PDT）组，接种瘤细胞后第6无尾静脉注入磺化铝酞菁（ALSPc）10～20mg／kg，24小时后肿瘤部位照红光。热疗组，大腿部肿瘤用微波热疗（42．5℃、20分钟）或脚垫部肿瘤浸入恒温水浴内（44℃、25分钟）。合并治疗组，先行PDT治疗，10分钟后进行热疗。单独热疗或单独PDT治疗，小鼠肿瘤受到明显抑制，4O天内有50％左右肿瘤消退。合并治疗组对肿瘤的抑制更为显著，第20天和第40天的肿痛消退率分别比单纯热疗组和单纯PDT组高，统计上差异显著。
Kunming mice were inoculated ascites with hepatic carcinoma subcutaneously on the right hind footpad or right thigh lateral and randomly divided into groups. In the photodynamic therapy (PDT) group, the 6th tail vein was injected into the luminal phthalocyanine (ALSPc) 10 to 20 mg/kg after inoculation of the tumor cells, and the tumor site was irradiated with red light 24 hours later. In the hyperthermia group, tumors in the thighs were immersed in a thermostatic water bath (44°C, 25 minutes) by microwave hyperthermia (42.5°C, 20 minutes) or footpad tumors. In the combined treatment group, PDT was first performed and hyperthermia was performed 10 minutes later. Hyperthermia alone or PDT alone significantly suppressed tumors in mice, with approximately 50% of tumors regressing within 40 days. The inhibition of tumors in the combined treatment group was even more significant, and the extinction rate of swelling on the 20th and the 40th day was higher than that of the hyperthermia group and the PDT alone group, and the difference was statistically significant.