论文部分内容阅读
目的通过对黑龙江省哈尔滨市各类型初诊白血病患者的年龄和性别进行统计分析,探讨该地区白血病的流行分布特点。方法选取2010年1月至2011年12月间哈尔滨血液病肿瘤研究所和哈尔滨医科大学附属各医院收治的1427例各类型白血病初诊患者的骨髓穿刺结果,结合流式细胞术、骨髓活检、分子生物学检测和染色体分析对患者进行白血病确诊并分型。结果急性白血病患者1059例,占74.2%,平均发病年龄(33±19.8)岁。其中髓系白血病(AML)患者742例,占70.1%,平均发病年龄(38±18.0)岁;急性淋巴细胞白血病(ALL)患者317例,占29.9%,平均发病年龄(21±18.7)岁。慢性白血病患者368例,占25.8%,平均发病年龄(47±16.8)岁。在慢性粒-单核细胞白血病和21~40岁年龄组中,急性白血病女性患者居多,而其他各组男性白血病患者居多。所有白血病患者中,41~60岁年龄组分布最高。急性白血病患者主要分布于0~20岁年龄组,且随着年龄增长,分布比例逐渐减低。而慢性白血病主要分布于41~60岁年龄组,且在0~60岁范围内,慢性白血病的分布比例随着年龄的增长逐渐增加。结论黑龙江省哈尔滨市地区白血病患者以中老年(41~60岁)男性居多,急性白血病患者比例明显高于慢性白血病且多分布于青少年,白血病各亚型的分布与年龄有一定的相关性。
Objective To analyze the age and gender of newly diagnosed leukemia patients in Harbin City, Heilongjiang Province, and to explore the epidemiological distribution of leukemia in this region. Methods The bone marrow puncture results of 1427 newly diagnosed leukemia patients from Harbin Institute of Hematology and Oncology between January 2010 and December 2011 were collected and combined with flow cytometry, bone marrow biopsy, and molecular biology. Scientific tests and chromosomal analysis diagnose and classify patients with leukemia. Results There were 1059 cases of acute leukemia, accounting for 74.2%, and the average age of onset was (33±19.8) years. Among them, 742 patients with myeloid leukemia (AML) accounted for 70.1%, and the average age of onset (38±18.0) years; 317 patients with acute lymphoblastic leukemia (ALL) accounted for 29.9%, and the average age of onset was (21±18.7) years. 368 cases of chronic leukemia patients, accounting for 25.8%, the average age of onset (47 ± 16.8) years. In chronic myelomonocytic leukemia and 21 to 40 years of age groups, female patients with acute leukemia are predominant, while leukemia patients in other groups are predominant. Among all leukemia patients, the 41-60 age group had the highest distribution. Patients with acute leukemia are mainly distributed in the 0-20 year age group, and as the age increases, the distribution ratio gradually decreases. The chronic leukemia is mainly distributed in the 41 to 60-year-old age group, and in the 0 to 60-year-old range, the distribution of chronic leukemia gradually increases with age. Conclusion The majority of patients with leukemia in Harbin, Heilongjiang Province were middle-aged (41-60 years old) males. The proportion of acute leukemia patients was significantly higher than that of chronic leukemia patients and mostly distributed in adolescents. The distribution of leukemia subtypes was correlated with age.