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目的：实验观察维生素Ａ对色拉油烟冷凝物致小鼠毒性作用的影响。方法：采用微核试验和精子畸形分析方法，观察维生素Ａ对色拉油烟冷凝物致小鼠微核率和精子畸形率作用的影响，并作Ｐｏｉｓｓｏｎ分布资料的ｕ检验。结果：色拉油烟冷凝物５ｍｌ／ｋｇ组和１０ｍｌ／ｋｇ组小鼠的微核率和精子畸形率均显著地高于２．５ｍｌ／ｋｇ组和单纯色拉油对照组（Ｐ＜０．０１），而２．５ｍｌ／ｋｇ组未显示致小鼠微核率和精子畸形率升高作用（Ｐ＞０．０５）；给小鼠补充维生素Ａ后，可明显地减弱色拉油烟冷凝物致小鼠微核率和精子畸形率升高的作用（Ｐ＜０．０１）。结论：色拉油烟冷凝物可致小鼠微核率和精子畸形率明显升高，而补充维生素Ａ后可降低其毒性作用。
Objective: To observe the effect of vitamin A on toxicity induced by salad oil smoke condensate in mice. Methods: The micronucleus test and sperm deformity analysis were used to observe the effect of vitamin A on the micronucleus rate and sperm deformity rate in mice induced by salad oil smoke condensate. The Poisson distribution data were tested by u test. Results: The micronucleus rate and sperm abnormality rate of 5ml / kg group and 10ml / kg group were significantly higher than that of 2.5ml / kg group and control group (P <0.01) While the 2.5ml / kg group did not show micronucleus rate and sperm abnormality rate increased (P> 0.05). Vitamin A supplementation in mice significantly attenuated the mice induced by the condensation of safflower soot Nuclear rate and sperm abnormality rate increased (P <0.01). CONCLUSIONS: Salad soot condensate can significantly increase the micronuclei rate and sperm abnormality in mice, while vitamin A supplementation can reduce its toxicity.