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目的 比较几种常用的中枢兴奋药和催眠药对小鼠自主活动影响的量效和时效特征。 方法 以雄性小鼠为实验对象。中枢兴奋药实验分７ 组（ｎ＝ ６）：①对照组；②咖啡因（Ｃａｆ）１５ｍ ｇ／ｋｇ；③Ｃａｆ ３０ ｍ ｇ／ｋｇ；④Ｃａｆ６０ ｍ ｇ／ｋｇ；⑤右旋苯丙胺（Ｄｅｘ） ５ ｍ ｇ／ｋｇ；⑥Ｄｅｘ １０ ｍ ｇ／ｋｇ；⑦Ｄｅｘ ２０ｍ ｇ／ｋｇ。催眠药实验分７ 组（ｎ＝ ６）：①对照组；②三唑仑（Ｔｒｉ） ０．０４ ｍ ｇ／ｋｇ；③Ｔｒｉ０．０８ ｍ ｇ／ｋｇ；④速可眠（Ｓｅｃ） ６０ ｍ ｇ／ｋｇ；⑤Ｓｅｃ １２０ ｍ ｇ／ｋｇ；⑥褪黑素（Ｍｅｌ）１２０ ｍ ｇ／ｋｇ；⑦Ｍｅｌ２４０ ｍ ｇ／ｋｇ。分别于昼（８：３０～９：００）、夜（２０：００～２１：００）一次性灌胃给药，对照组给予等量蒸馏水。用仪器自动记录小鼠自主活动１ ｈ（催眠药）或５ ｈ（兴奋药），计算其自主活动数（ｘ±ｓ）和药物对小鼠自主活动的抑制率（％ ）。此外，观察用药后小鼠自主活动的变化趋势。 结果 ①小鼠自主活动存在昼夜节律，夜间相对活跃；②昼间给予中枢兴奋药可明显提高小鼠自主活动。Ｃａｆ的量效关系不明显，而三个剂量的Ｄｅｘ 以１０ｍ ｇ／ｋｇ作用最强。然而夜间给予Ｃａｆ的效应?
Objective To compare the effects of several commonly used central stimulants and hypnotics on the autonomic activity of mice. Methods Male mice were used as experimental subjects. The central stimulant drug experiment was divided into 7 groups (n = 6): ① control group; ② Caffeine 15 m g / kg; ③ CaF 30 m g / kg; ④ CaF 60 m g / kg; g / kg; ⑥ Dex 10 m g / kg; ⑦ Dex 20 m g / kg. Hypnotics test was divided into 7 groups (n = 6): ① control group; ② Triazolam 0.04 m g / kg; Triri 0.08 m g / kg; ④ Sit 60 m g / kg; ⑤ Sec 120 m g / kg; ⑥ Melatonin (Mel) 120 m g / kg; ⑦ Mel 240 mg / kg. The rats were given gavage once daily (8: 30-9: 00) and night (20: 00-21: 00) respectively. The control group was given the same amount of distilled water. The autonomic activity of mice was recorded for 1 h (hypnotics) or 5 h (stimulants) automatically, and the number of autonomic activities (x ± s) and the inhibition rate (%) of drugs on autonomic activity were calculated. In addition, observe the trend of autonomic activity of mice after treatment. Results ① The circadian rhythms of autonomic activity in mice were relatively active at night; ② Central stimulants in the daytime could significantly improve autonomic activity in mice. The dose-effect relationship of Caf was not obvious, but Dex of three doses had the strongest effect at 10 m g / kg. However, given the effect of Caf at night?