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氧氟沙星(ofloxacin)是喹诺酮类的衍生物之一,它是一种广谱、高效、毒性较低的新型po抗菌药物.为了扩大药物剂型,充分发挥药物剂型对药物作用的影响,我们试制了氧氟沙星栓剂,并测定了其在人体尿液中的浓度.其方法简便快速,结果可靠.1 实验材料1.1 仪器 UV—210A分光光度计(日本岛津),751-G型紫外分光光度计(上海分析仪器厂).1.2 药品与试剂 氧氟沙星对照品(广东丽珠制药厂,含量测定99.71%,批号920602);氧氟沙星栓剂由本院药剂实验室自制,其质量标准符合《中国药典》1995版有关栓剂项下的规定.三氯醋酸、氢氧化钠均为分析纯.
Ofloxacin is one of the derivatives of quinolones, which is a new broad-spectrum, high-potency and less toxic newer antimicrobial po.In order to expand the dosage form and to exert the full effect of drug dosage form on the drug effect, we Ofloxacin suppository was tested, and its concentration in human urine was determined.The method is simple and fast, the results are reliable.Experimental material 1.1 Instrument UV-210A spectrophotometer (Japan Shimadzu), Model 751-G UV Spectrophotometer (Shanghai Analytical Instrument Factory) .1.2 Drugs and reagents ofloxacin reference substance (Guangdong Livzon Pharmaceutical Factory, content determination of 99.71%, lot number 920602); ofloxacin suppository homemade pharmacy laboratory, its Quality standards in line with the “Chinese Pharmacopoeia” 1995 version of suppository under the provisions of trichloroacetic acid, sodium hydroxide are of analytical grade.