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甲氧苄啶(Trimethoprim,TMP)本身是一个广谱抗菌剂,它与中效磺胺,如磺胺甲噁唑(新诺明,SMZ)、磺胺嘧啶(SD)等按一定配比,能取得协同抗菌效果。另据报道,TMP对抗生素类也能增加抗菌作用,尤其对四环素和庆大霉素有明显增效作用。自1975年以来,我国有些省市已制订了“增效四环素片的质量标准,我省也有药厂申请报批生产四环素增效片,委托我所检验。我们首先针对TMP能否增加四环素的抗菌效果进行试验,根据中国药典一九七七年版四环素微生物杯碟法,并参照其他省市制订
Trimethoprim (TMP) itself is a broad-spectrum antibacterial agent that achieves synergism with midazolam, such as sulfamethoxazole (SMZ) and SD (Sulfadiazine) Antibacterial effect. It is also reported that TMP antibiotics can also increase the antimicrobial effect, especially tetracycline and gentamicin synergy. Since 1975, some provinces and cities in our country have enacted the quality standards for tetracyclines and the pharmaceutical companies in our province have applied for the approval for the production of tetracycline and have commissioned the tests. We first examined whether TMP can increase the antibacterial effect of tetracycline According to the Chinese Pharmacopoeia 1977 edition of the tetracycline microbe cup method, and with reference to the formulation of other provinces and cities