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本文分析30例(平均年龄41岁)氟性主动脉硬化症的血清脂蛋白定量,并以健康成人31名(平均年龄40.5岁)为对照组。两组均检测T-ch、HDL、LDL、VLDL、HDL/T-ch,进行显著性t检验及相关性分析。结果表明氟病组HDL,HDL/T-ch明显低于对照组,VLDL高于对照组,但各值均未超过正常值。VLDL、LDL及T-ch与二维超声心动图主动脉壁厚度呈正相关,r各为0.45,0.54和0.55。讨论了氟性主动脉硬化形成机制与血清脂质的关系,除了与Ca~++内流增多使肌细胞功能衰竭而坏死造成局部钙化及溃疡外,可能与氟离子和体内酶系的重要协同作用有关;氟的摄入过量可能使机体酶系功能失调,导致血VLDL增高,HDL减少,使血管壁发生病理改变。
This article analyzes the quantitative determination of serum lipoproteins in 30 patients (mean age 41 years) with FFA and 31 healthy adults (mean age 40.5 years) as control group. T-ch, HDL, LDL, VLDL and HDL / T-ch were detected in both groups, and significant t-test and correlation analysis were performed. The results showed that the HDL, HDL / T-ch in the fluorosis group were significantly lower than those in the control group, but VLDL was higher than that in the control group, but the values did not exceed the normal values. VLDL, LDL and T-ch and two-dimensional echocardiography aortic wall thickness was positively correlated, r each 0.45,0.54 and 0.55. The relationship between the formation mechanism of FFA and serum lipid was discussed. In addition to the increase of Ca ~ + + influx, the muscle cells failed to function and the necrosis caused local calcification and ulceration, which may be related to the important synergism between fluoride ion and in vivo enzyme system Effect; fluoride intake may make the body dysfunction of enzyme system, leading to increased blood VLDL, HDL decreased, the pathological changes in the vessel wall.