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肿瘤细胞多药耐药的发生是肿瘤化疗失败的主要原因之一。细胞膜上P糖蛋白(Pgp)的过度表达是多药耐药的最主要发生机制,有效抑制Pgp的表达可逆转肿瘤的多药耐药性,延长患者的生存时间。Pgp抑制剂是目前研究的热点之一,本文就Pgp抑制剂的研究进展进行综述。
The occurrence of multidrug resistance in tumor cells is one of the main reasons for the failure of chemotherapy. Overexpression of P-glycoprotein (Pgp) on the cell membrane is the most important mechanism of multidrug resistance. Effective inhibition of Pgp expression can reverse multidrug resistance of tumors and extend the survival time of patients. Pgp inhibitor is one of the hot spots in the current research. This article reviews the research progress of Pgp inhibitor.