论文部分内容阅读
目的探讨毛细支气管炎患儿血清细胞因子水平变化及其临床意义。方法采用ELISA法检测观察组30例毛细支气管炎患儿和对照组30例正常小儿血清中白介素10、白介素4以及肿瘤坏死因子α水平,并对两组数据进行观察比较。结果观察组血清中TNF-α和IL-4水平明显高于对照组(P<0.05),血清中IL-10水平低于对照组,差异有统计学意义(P<0.05)。结论小儿毛细支气管炎的发病与患儿血清中TNF-α、IL-4以及IL-10水平有密切关系,研究其水平变化对预防发展为哮喘有重要意义。
Objective To investigate the changes of serum cytokines in children with bronchiolitis and its clinical significance. Methods Serum levels of interleukin 10, interleukin 4 and tumor necrosis factor α were detected in 30 children with bronchiolitis and 30 normal children in the observation group by ELISA. The data of two groups were observed and compared. Results The levels of TNF-α and IL-4 in the serum of the observation group were significantly higher than those of the control group (P <0.05), while the level of IL-10 in the serum was lower than that of the control group (P <0.05). Conclusions The incidence of bronchiolitis in children is closely related to the levels of TNF-α, IL-4 and IL-10 in children. It is of great significance to study the changes of the levels in the prevention of the development of asthma.