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作者认为对控制慢性房颤的心室率地高辛是最适合的药物。然而,常需联合应用一种β阻滞剂或钙通道阻滞剂。遗憾的是,某些病人甚至对这种联合用药也无反应;另有一些病人则产生副作用。Roden等观察了高血压病人长期口服氯压定每12小时0.2～0.5mg,对电生理学和血液动力学的影响,此种剂量轻度降低舒张血压,而明显减慢窦率和增加心房起搏,引起房室结的文氏观象。氯压定也明显地增加和纠正窦房结的恢复时间。Roth等应用单剂小量(0.075mg)的氯压定控制快速房颤病例的心室率。为了评价氯压定对地高辛(0.25～0.375mg/日)未能控制慢性房颤快速心室率的效果(休息心室率
The authors believe that ventricular rate control of chronic atrial fibrillation digoxin is the most suitable drug. However, it is often necessary to combine a beta blocker or calcium channel blocker. Unfortunately, some patients do not even respond to this combination; others have side effects. Roden et al observed the effects of long-term oral clonidine 0.2 to 0.5 mg every 12 hours on electrophysiology and hemodynamics in hypertensive patients, which slightly reduced diastolic blood pressure while significantly slowing sinus rates and increasing atrial pacing , Causing atrioventricular node of Venus. Clonidine also significantly increases and corrects sinus node recovery time. Roth and other small single dose (0.075mg) of chlorine pressure to control ventricular rate in patients with atrial fibrillation. In order to evaluate the effect of clonidine on digoxin (0.25-0.375 mg / day) failed to control the rapid ventricular rate in patients with chronic atrial fibrillation (resting ventricular rate