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目的了解邯郸市乙肝病毒基因型分布情况,并探讨其与临床的关系。方法采用PCR-RFLP方法对邯郸108份HBV感染者的血清进行基因型分型,并结合转氨酶和HBV-DNA结果,分析乙肝病毒基因型的临床意义。结果邯郸市慢性乙肝人群感染的HBV主要以C基因型为主,占93.5%,B基因型占6.5%。不同性别感染基因型差异无统计学意义。肝生化指标ALT、AST、TB比较提示C基因型患者的肝脏炎症似乎比B型患者重,但差异无统计学意义。C基因型的患者血清HBeAg阳性率高于B基因型。C基因型的患者血清HBV-DNA略高于B基因型,但无统计学差异。结论邯郸市慢性乙肝人群感染的HBV主要以C基因型为主。C基因型患者血清HBeAg阳性率高于B基因型,C基因型患者与B基因型相比肝脏炎症较重,HBV-DNA略高,但差异无统计学意义。
Objective To understand the distribution of Hepatitis B virus genotypes in Handan City and to explore its relationship with clinical. Methods The genotypes of 108 HBV infected individuals in Handan were genotyped by PCR-RFLP. The clinical significance of hepatitis B virus genotypes was analyzed based on the results of transaminase and HBV-DNA. Results The HBV genotypes in chronic hepatitis B patients in Handan City were mainly C genotype, accounting for 93.5% and B genotype accounting for 6.5%. There was no significant difference in genotypes between different genders. Comparisons of liver biochemical markers ALT, AST and TB suggest that liver inflammation in patients with genotype C seems to be more severe than in patients with type B, but the difference was not statistically significant. The serum HBeAg positive rate of patients with genotype C was higher than that of genotype B. Serum HBV-DNA of patients with genotype C was slightly higher than genotype B, but there was no significant difference. Conclusion The HBV genotypes in Chronic Hepatitis B in Handan City are mainly C genotypes. The positive rate of serum HBeAg in patients with genotype C was higher than that of genotype B, and the genotype C patients had more severe liver inflammation and HBV-DNA than genotype B, but the difference was not statistically significant.