40年前已知限制热量摄入可减少人类癌症,尤其是结肠癌与乳腺癌的发生和延长寿命,同时也是预防实验动物发生肿瘤的有效方式之一。美国Wisconsin大学的Pariza等建立了一种标准的实验性乳腺癌模型。给断乳的大鼠以一定成分的食物,其中含5％的植物油。当鼠龄52天时各鼠接受致癌物(7.8-二甲基苯蒽)处理,然后分成三组。I组为高脂肪饮食自由摄取组,食物中含植物油30％;Ⅱ组为低脂肪饮食自由摄取组;Ⅲ组为高脂肪饮食、限制性摄取组,食物中含植物油30％。三组动物从每日消耗 40 years ago, known to limit calorie intake can reduce human cancers, especially colon cancer and breast cancer, and prolong life, but it is also an effective way to prevent tumors in experimental animals. Pariza et al. (University of Wisconsin, USA) established a standard experimental breast cancer model. Weaned rats were given a certain amount of food containing 5% vegetable oil. When rats were 52 days old, each mouse was treated with a carcinogen (7.8-dimethylbenzoquinone) and then divided into three groups. Group I was a high-fat diet free ingestion group. Foods contained 30% vegetable oil; Group II was a low-fat diet free intake group; Group III was a high-fat diet, a restricted intake group, and food contained 30% vegetable oil. Three groups of animals consumed daily