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目的 探讨不明原因高间接胆红素血症(高胆)的临床特点及其相关因素。方法 对我院1990年～1999年收治的不明原因高胆足月新生儿316例进行回顺性分析。结果 不明原因高胆患儿占同期高胆住院患儿的20.5％(316/1 539),男∶女=1.6∶1,轻度占20.6％(65/316),中度占61.7％(195/316),重度占17.7％(56/316)。重度组母O型血所占比例和母子血型不合发生率高于轻、中度组,差异有显著性(P<0.05)。重度组胆红素值降到正常时间及光疗时间明显长于其它2组,差异有显著性(P<0.05)。结论 母亲O型血型可能为新生儿高胆发生和发展的危险因素。轻度高胆组可能包含有生理性黄疸,重度组可能包括部分新生儿ABO血型不合溶血病。
Objective To investigate the clinical features and related factors of indirect hyperbilirubinemia (hypercholesterolemia) with unknown causes. Methods A retrospective analysis of 316 newborns with full-term high-risk full-term newborns admitted to our hospital from 1990 to 1999 was conducted. The results of unknown causes of children with gallbladder accounted for 20.5% (316/1 539) of children with gallbladder in the same period, male: female = 1.6: 1, mild accounted for 20.6% (65/316), moderate accounted for 61.7% (195 / 316) and severe (17.7% (56/316)). Severe group of mother’s O-type blood and maternal and child blood group was higher than the incidence of non-mild group, the difference was significant (P <0.05). Serum bilirubin levels in severe group decreased to normal time and phototherapy time was significantly longer than the other two groups, the difference was significant (P <0.05). Conclusion The mother’s O blood group may be a risk factor for neonatal hypercholesterolemia and development. Mild hyponatremia group may include physiological jaundice, severe group may include some neonatal ABO incompatible hemolytic disease.