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糖尿病周围神经病变是糖尿病常见的慢性并发症和主要致残因素之一,其病因主要是长期严重的高血糖及由此而导致的代谢障碍、微循环障碍和自身免疫功能紊乱。目前有效的治疗方法不多。临床症状以对称性肢体疼痛、麻木和感觉减退为主要特征。单唾液酸神经节苷脂(GM1)具有增强体内营养因子作用,减缓或中断周围神经髓鞘脱失,促进神经的生长和髓鞘的修复。作者对39例糖尿病周围神经病变患者应用GM1治疗4周随机对照观察,结果报道如下。1资料和方法
Diabetic peripheral neuropathy is one of the common chronic complications and major disability factors of diabetes. Its causes are mainly long-term severe hyperglycemia and the resulting metabolic disorders, microcirculation disorders and autoimmune disorders. The current effective treatment is not much. Clinical symptoms are characterized by symmetrical limb pain, numbness and loss of sensation. Monosialoganglioside (GM1) enhances the role of trophic factor in the body, slows or interrupts peripheral nerve demyelination, promotes nerve growth and myelin repair. The authors of 39 cases of diabetic peripheral neuropathy patients treated with GM1 4 weeks randomized controlled trials, the results reported below. 1 data and methods