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MDM2 (the product of murine double minute 2 gene) is one of the most important negative regulators of p53,which can binds to p53 and initiates ubiquitin-mediated degradation.Besides,MDM2 also controls the activity of several cell-cycle regulators,e.g.pRB,p21,E2F1,independently of p53.The important role of MDM2 in cell-cycle regulation indicates it to be a point of interest in cancer research.In recent years,studies revealed that MDM2 participated in the genesis and development of human tumors.The expression levels and activity of MDM2 was associated with the invasion,metastasis,prognosis and more practical,chemosensitivity.MDM2 is becoming a novel biomarker in cancer prognosis and chemosensitivity prediction.
The product of murine double minute 2 gene is one of the most important negative regulators of p53, which can binds to p53 and initiates ubiquitin-mediated degradation. Besides, MDM2 also controls the activity of several cell-cycle regulators, egpRB , p21, E2F1, independently of p53. The important role of MDM2 in cell-cycle regulation suggests it to be a point of interest in cancer research. recent years, studies revealed that MDM2 participated in the genesis and development of human tumors. expression levels and activity of MDM2 was associated with the invasion, metastasis, prognosis and more practical, chemosensitivity. MDM2 is becoming a novel biomarker in cancer prognosis and chemosensitivity prediction.