本文对十年前河南地区３０２名献血员的丙型肝炎病毒（ＨＣＶ）血清学指标进行了回顾性调查，结果抗－ＨＣＶ、抗－ＨＣＶ－ＩｇＭ和ＨＣＶＲＮＡ检出阳性者分别为３例、１例、１例，阳性率各为０．９９％、０．３３％和０．３３％。男女献血员抗－ＨＣＶ检出率分别为１．１０％和０．８３％，差异无显著性意义（Ｐ＜０．０５）。其中１例抗－ＨＣＶ－ＩｇＭ、ＨＣＶＲＮＡ均阳性，而抗－ＨＣＶ阴性，故ＨＣＶ总感染率为１．３２％。结果显示，十年前河南地区献血员与一般人群丙型肝炎病毒感染状况相似，感染率很低。 This article retrospectively investigated the serological indicators of hepatitis C virus (HCV) in 302 blood donors in Henan Province 10 years ago. Results The positive rates of anti-HCV, anti-HCV-IgM and HCV RNA were 3 In one case, the positive rates were 0.99%, 0.33% and 0.33% respectively. The detection rates of anti-HCV in male and female blood donors were 1.10% and 0.83%, respectively, with no significant difference (P <0.05). One case of anti-HCV-IgM, HCVRNA were positive, and anti-HCV negative, so the total HCV infection rate was 1.32%. The results showed that a decade ago, blood donors in Henan Province and the general population of hepatitis C virus infection status is similar, the infection rate is very low.