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严重急性胰腺炎(SAP)由于全身炎性反应综合征导致多器官衰竭而引起较高的病死率。至今,除了支持性重症监护疗法之外还没有治疗SAP的有效方法。为降低病死率,一些新的药物应用于实验性胰腺炎。最常用于实验研究的急性胰腺炎(AP)动物模型有三种,即蛙皮素、牛磺酸钠和无胆碱而乙硫氨酸充足的饮食(CDE)引起的水肿性或出血性胰腺炎。本文依据不同模型复制方法,对近年来实验治疗或取得的结果进行综述。许多方法包括蛋白酶抑制剂,抗炎性因子治疗,超氧化物治疗,核因子κB抑制剂治疗,血管加压素治疗,高压氧治疗等,已经显示出抗胰腺炎的保护作用。
Severe acute pancreatitis (SAP) causes a higher case fatality rate due to multiple organ failure caused by systemic inflammatory response syndrome. To date, there is no effective way to treat SAP beyond supportive intensive care therapy. In order to reduce the mortality rate, some new drugs should be used in experimental pancreatitis. There are three animal models of acute pancreatitis (AP) that are most commonly used in experimental studies, namely encephalomalaemorrhagic or hemorrhagic pancreatitis caused by bombesin, sodium taurinate and a choline-free, ethionine-rich diet (CDE) . This article based on different models of replication methods, experimental treatment in recent years or the results obtained are reviewed. Many methods include protease inhibitors, anti-inflammatory factor therapy, superoxide therapy, treatment of inhibitors of nuclear factor kappa B, vasopressin therapy, hyperbaric oxygen therapy, etc., have shown protective effects against pancreatitis.