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目的 观察增殖细胞抗原 (PCNA)在胃粘膜肠上皮化生、异型增生及胃癌中的表达情况 ,评估癌前病变的发展趋势。方法 免疫组织化学方法。结果 PCNA在细胞核内表达 ,从肠上皮化生、异型增生到胃癌呈递增趋势 ,在肠上皮化生表现为轻度表达 ,异型增生以中度为主 ,而胃癌多呈重度和过度表达。结论 PCNA在胃粘膜不同疾病细胞核内的表达 ,反映了细胞增殖状态和生长速度 ,有助于判断肠上皮化生、异型增生的发展趋势及胃癌的预后
Objective To observe the expression of proliferating cell antigen (PCNA) in gastric mucosal intestinal metaplasia, dysplasia and gastric cancer and evaluate the development trend of precancerous lesions. Methods Immunohistochemistry. Results The expression of PCNA in the nucleus was increased from intestinal metaplasia and dysplasia to gastric cancer. The expression of PCNA was mild in intestinal metaplasia, moderately predominant in dysplasia, and severe and over-expression in gastric cancer. Conclusions The expression of PCNA in the nucleus of different gastric mucosal diseases reflects the proliferation status and growth rate of PCNA, which is helpful to determine the developmental tendency of intestinal metaplasia and dysplasia and the prognosis of gastric cancer