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目的探讨米非司酮序贯益气化瘀中药治疗子宫肌瘤的临床疗效。方法将98例子宫肌瘤患者随机分为3组:A组服用益气化瘀中药;B组前一疗程服用米非司酮、后一疗程服用益气化瘀中药,C组单纯服用米非司酮。3个月为1个疗程,连用2个疗程。观察各组治疗前、治疗期间及停药后肌瘤体积大小,检测血清雌二醇(E2)水平,并评价临床症状缓解情况及副作用。结果各组临床症状均较治疗前明显改善(P<0.05)。其中,第1疗程B、C两组的有效率均显著高于A组(P<0.01),但E2水平较A组明显降低(P<0.05),更年期症状评分明显升高(P<0.05);第2疗程B、C两组的有效率仍然高于A组(P<0.05),但B组E2水平有所提高、更年期症状显著改善,而C组E2水平持续降低、更年期症状进一步加重。停药后3月,C组的复发率明显高于A、B组(P<0.05);停药6月,C组的复发率进一步增高,临床症状复发。结论米非司酮联合益气化瘀药物序贯疗法可使子宫肌瘤体积明显缩小,且临床副反应小,停药后复发率低。
Objective To investigate the clinical efficacy of mifepristone sequential Yiqi Huayu Chinese medicine treatment of uterine fibroids. Methods 98 patients with uterine fibroids were randomly divided into three groups: Group A taking Yiqi Huayu Chinese medicine; Group B before taking a course of treatment of mifepristone, the latter course of treatment taking Yiqi Huayu medicine, C group taking only non-Mifei Division ketone. 3 months for a course of treatment, once every 2 courses. The volume of fibroids in each group before treatment, during treatment and after drug withdrawal were measured, serum estradiol (E2) levels were measured, and clinical symptoms and side effects were evaluated. Results The clinical symptoms of all groups were significantly improved compared with those before treatment (P <0.05). Among them, the effective rate of the first course of treatment B and C were significantly higher than that of the A group (P <0.01), but the level of E2 was significantly lower than that of the A group (P <0.05), the score of menopausal symptoms was significantly increased (P <0.05) (P <0.05). However, the effective rate of group B and C in the second course of treatment was still higher than that in group A (P <0.05). However, the level of E2 in group B was improved and the symptom of menopause was significantly improved. The level of E2 in group C continued to decrease and the symptom of menopause was further aggravated. The recurrence rate of group C was significantly higher than that of group A and B (P <0.05) after 3 months of withdrawal. The relapse rate of group C further increased and the clinical symptoms recurred in June. Conclusion Mifepristone combined with Yiqi Huayu sequential therapy can significantly reduce the volume of uterine fibroids, and clinical side effects, low recurrence rate after stopping.