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1940年青霉素问世以来,迄今仍为控制革兰氏阳性球菌感染的首选药物。由于青霉素钠盐产量低,临床大量使用钾盐,该药肌肉注射时疼痛显著,故国内五十年代用0.25％普鲁卡因作为溶媒曾风行一时。后因酱鲁卡因过敏时有发生,以及普鲁卡因青霉素、普鲁卡因青霉素油悬剂不慎注入血管可形或栓塞,甚至导致死亡者,故摒弃使用。七十年代初不少地区用2％苯甲醇代替注射用水作溶媒,以减轻局部疼痛,受到病人普遍欢迎。国外
Since the advent of penicillin in 1940, so far is the drug of choice for controlling Gram-positive cocci infection. Due to the low production of penicillin sodium, the clinical use of large amounts of potassium, the drug intramuscular injection pain was significant, so the domestic fifties with 0.25% procaine as a vehicle has been popular for a while. After the due to the allergic reaction of Sauvignon have occurred, and procaine penicillin, procaine penicillin oil suspension inadvertently injected into the blood vessels may form or embolism, and even lead to death, it abandoned. In the early 1970s, 2% benzyl alcohol instead of water for injection was used as vehicle in many areas to reduce local pain and was widely welcomed by patients. foreign