本文用免疫组织化学技术,研究了人和大鼠脊髓内P物质阳性结构的分布。结果显示,在后角的Ⅰ～Ⅲ层和李氏束有密集的P物质免疫反应阳性神经纤维和终末,排列呈点线状或密网状,染为黄色、褐色或暗褐色。在中央管周围也有较密的P物质阳性纤维;而脊髓的腹侧角,这类阳性纤维较为稀疏。此外,在大鼠脊神经节中,我们观察到P物质免疫反应的阳性神经元胞体,属于小型细胞。 Immunohistochemistry was used to study the distribution of substance P-positive structures in the spinal cord of human and rat. The results showed that in the posterior angle Ⅰ ~ Ⅲ and Lee bundle with dense substance P immunoreactive nerve fibers and terminals, arranged in a dotted line or dense network, dyed yellow, brown or dark brown. Around the central tube also has a more dense P substance-positive fibers; the ventral horn of the spinal cord, these positive fibers are more sparse. In addition, in rat spinal ganglia, we observed positive neurons of substance P immune response, belonging to small cells.