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老年人骨髓造血和免疫系统功能随年龄增长而下降,近年来随着皮质激素和免疫抑制剂的广泛应用,使老年人败血症日益增多,预后甚差。为此对我院1986年7月至1992年7月老年人因使用激素及免疫抑制剂而导致败血症的28例加以分析。 1 临床资料 28例中,男18例,女10例。年龄60～69岁21例,70～82岁7例,平均67岁。6例为院外感染,22例为院内感染。原发病:淋巴瘤6例,急性白血病、血小板减少性紫癜及慢性肾小球肾炎各5例,自身免疫性溶血性贫血4例,红斑狼疮3例。全部病例均使用皮质激素及免疫抑制剂,泼尼松30～60mg/日或地塞米松4.5～9.0mg/日,同时合并使用1～3种免疫抑制剂(如环磷酰胺、氨甲喋呤、长春新碱、阿糖胞
Elderly bone marrow hematopoietic and immune system function decline with age, in recent years with the widespread use of corticosteroids and immunosuppressive agents, so that the elderly sepsis increasing, the prognosis is poor. To this end our hospital from July 1986 to July 1992 the elderly due to the use of hormones and immunosuppressive agents cause sepsis in 28 cases were analyzed. A clinical data of 28 cases, 18 males and 10 females. 21 cases aged 60 to 69 years old, 70 to 82 years old in 7 cases, an average of 67 years old. Six cases were nosocomial infections and 22 were nosocomial infections. Primary disease: 6 cases of lymphoma, acute leukemia, thrombocytopenic purpura and chronic glomerulonephritis in 5 cases, 4 cases of autoimmune hemolytic anemia, lupus erythematosus in 3 cases. All cases were treated with corticosteroids and immunosuppressive agents, prednisone 30 ~ 60mg / day or dexamethasone 4.5 ~ 9.0mg / day, combined with 1 ~ 3 kinds of immunosuppressive agents (such as cyclophosphamide, methotrexate, Changchun new Alkali, arabinose