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目的研究中国西沙群岛海绵Dysidea granulosa的化学成分。方法利用薄层色谱、硅胶色谱、Sephadex LH-20色谱、MPLC、半制备HPLC等方法对化学成分进行分离纯化;通过NMR、MS等方法,并结合文献,鉴定化合物的结构。结果从西沙海绵Dysidea granulosa的甲醇粗提取物中,分离得到6个化合物:Honulactone A(1),Honulactone B(2),Honulactone E(3),Honulactone F(4),2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol(5),3,5-Dibromo-6-chloro-2-(2,4-dibromophenoxy)phenol(6)。结论化合物1、2、3、4均为首次从该种海绵中分离得到。
Objective To study the chemical composition of the sponge Dysidea granulosa in the Xisha Islands of China. Methods The chemical constituents were separated and purified by thin-layer chromatography, silica gel chromatography, Sephadex LH-20, MPLC and semi-preparative HPLC. The structures of the compounds were identified by NMR, MS and other methods. Results Six compounds were isolated from the methanolic crude extract of Dysidea granulosa: Honulactone A (1), Honulactone B (2), Honulactone E (3), Honulactone F (4), 2- (2 ’, 4 ’-Dibromophenoxy) -4,6-dibromophenol (5), 3,5-Dibromo-6-chloro-2- (2,4-dibromophenoxy) phenol (6). Conclusion Compounds 1, 2, 3 and 4 were isolated from this sponge for the first time.