原发性胆汁性肝硬化(PBC)是由自身免疫引起的一种进展性、破坏性炎症疾病,其发病机理迄今未明,但一般认为胆管上皮免疫介导的损害起决定性作用。晚近认为,熊去氧胆酸(UDCA)是治疗 PBC 和慢性肝炎的有效制剂,其疗效作用可能部分是经由免疫机理介导。本实验研究了 UDCA 在体外对免疫球蛋白和细胞因子生成方面的免疫调节作用。 Primary biliary cirrhosis (PBC) is a progressive, destructive inflammatory disease caused by autoimmunity, and the pathogenesis of which is unknown so far, but it is generally believed that the bile duct epithelial immune-mediated damage plays a decisive role. Recently, ursodeoxycholic acid (UDCA) is considered an effective agent for the treatment of PBC and chronic hepatitis, and its curative effect may be partly mediated through immune mechanisms. This experiment investigated the immunomodulatory effects of UDCA on immunoglobulin and cytokine production in vitro.