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[目的]观察分析患者痰标本中金黄色葡萄球菌的临床分布和耐药情况。[方法]随机选取某人民医院的211株痰标本,检测其中是否含有甲氧西林敏感金黄色葡萄球菌(MSSA)与耐甲氧西林金黄色葡萄球菌(MRSA),并对其临床分布与耐药性情况进行观察及分析。[结果]211株痰标本主要来自神经外科、重症医学科与呼吸内科,均检出金黄色葡萄球菌,其中检出MRSA的126株,占59.72%;两种菌对利奈唑胺、万古霉素均不耐药;MRSA对10种抗生素的耐药性高于MSSA,差异有统计学意义(P<0.05)。MRSA对于庆大霉素、克林霉素、环丙沙星等药物具有较高的耐药性,MSSA仅对青霉素具有较高的耐药性。同时耐药的抗菌药物包括青霉素、红霉素、克林霉素等。211株菌株中,共150株发生耐多药。[结论]在痰标本中MSSA与MRSA均分布广泛,医院应加强卫生管理,做好消毒工作,以预防感染。
[Objective] To observe and analyze the clinical distribution and drug resistance of Staphylococcus aureus in sputum specimens of patients. [Method] A total of 211 sputum samples from a People’s Hospital were randomly selected to detect methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). The clinical distribution and drug resistance Sexual situation observation and analysis. [Results] Staphylococcus aureus was detected in 211 strains of sputum mainly from neurosurgery, critical care and respiratory medicine, of which 126 strains were detected, accounting for 59.72%. The two strains were sensitive to linezolid, vancomycin The drug resistance of MRSA to 10 kinds of antibiotics was higher than that of MSSA, the difference was statistically significant (P <0.05). MRSA for gentamicin, clindamycin, ciprofloxacin and other drugs with high resistance, MSSA only has high resistance to penicillin. At the same time resistant antibacterial drugs include penicillin, erythromycin, clindamycin and so on. Of 211 strains, a total of 150 strains developed multi-drug resistance. [Conclusion] Both MSSA and MRSA are widely distributed in sputum samples. The hospital should strengthen the hygiene management and do the disinfection work to prevent the infection.