【摘 要】
：
Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[1,2-b] pyridazine/imidazo[2,1-b]thiazole) groups were designed and sy
【出 处】
：
Chemical Research in Chinese Universities
论文部分内容阅读
Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[1,2-b] pyridazine/imidazo[2,1-b]thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ~ 1 H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.
Sixteen novel oxazolidinone analogs containing substituted thiazole / fused-bicyclic (imidazo [1,2-b] pyridazine / imidazo [2,1-b] thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ~ 1 H NMR, IR and MS, and their in vitro antibacterial activities were against as staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.
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