四氯化碳(CCl_4)具有原浆毒性,肝细胞对此尤为敏感,对其他肝小叶内细胞也有毒性作用,我们采用综合方法诱发大鼠肝硬变,在实验的不同时期处死动物,主要用电镜对肝硬变时假小叶内细胞超微形态进行了较为细致的观察,目的在于进一步了解肝硬变时肝内各种细胞的超微形态改变,希望能从而获得有助于阐明肝硬变形态发生的某些线索。 Carbon tetrachloride (CCl_4) with virgin plasma toxicity, liver cells are particularly sensitive to this, the hepatocytes in other lobular cells also have toxic effects, we use an integrated approach to induce cirrhosis in rats at different stages of the experiment to kill animals, the main use of Electron microscopy of liver cells in pseudolobule ultrastructure was more detailed observation, the purpose is to further understand the various morphological changes of liver cells in liver cirrhosis, hoping to get help to clarify the liver cirrhosis Some clues to morphogenesis.