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目的探讨血清脂联素水平与子宫内膜癌的临床关系。方法用酶联免疫法(ELISA法)检测50例子宫内膜癌患者(实验组)与50例健康女性(对照组)血清脂联素水平,分析血清脂联素水平与子宫内膜癌的关系。结果实验组患者平均血清脂联素水平[(4.36±1.24)mg/L]显著高于对照组[(15.33±2.48)mg/L](P<0.01);Ⅲ/Ⅳ期患者平均血清脂联素水平(4.09±1.93)mg/L,显著低于Ⅰ/Ⅱ期患者[(5.37±0.83)mg/L](P<0.05);肿瘤分化程度越高,血清脂联素水平越高;无淋巴结转移患者血清脂联素水平[(6.53±0.27)mg/L]显著高于有淋巴结转移患者血清脂联素水平[(4.05±0.84)mg/L](P<0.05);体内血清脂联素含量越低,患子宫内膜癌的风险越高(χ2=9.991,P<0.01,OR=0.851,95%CI为1.979,1.026,P<0.05)。结论血清脂联素水平在子宫内膜癌患者体内会降低,低水平血清脂联素是子宫内膜癌发生的独立危险因素。
Objective To investigate the clinical significance of serum adiponectin level and endometrial cancer. Methods The levels of serum adiponectin in 50 patients with endometrial carcinoma (experimental group) and 50 healthy women (control group) were detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between serum adiponectin level and endometrial carcinoma . Results The mean serum adiponectin level in the experimental group was significantly higher than that in the control group [(4.36 ± 1.24) mg / L [(15.33 ± 2.48) mg / L, P <0.01] (4.09 ± 1.93) mg / L, which was significantly lower than that in stage Ⅰ / Ⅱ [(5.37 ± 0.83) mg / L], the higher the degree of differentiation was, the higher the serum adiponectin level was; Serum levels of adiponectin in patients with lymph node metastasis (6.53 ± 0.27 mg / L) were significantly higher than those in patients with lymph node metastasis (4.05 ± 0.84 mg / L, P <0.05) The lower the content of uric acid, the higher the risk of endometrial cancer (χ2 = 9.991, P <0.01, OR = 0.851, 95% CI 1.979, 1.026, P <0.05). Conclusion The level of serum adiponectin in patients with endometrial cancer will be reduced, low serum adiponectin is an independent risk factor for endometrial cancer.