论文部分内容阅读
目的:对晚期胃癌常用化疗方案的疗效进行对比分析。方法:1997年7月至2000年12月我院收治的37例晚期胃癌患者,均经病理学和/或细胞学证实;FAM:5-Fu 600mg/m2.静滴.第1、8、29、36天;阿霉素30mg/m2静注,第1、29天,丝裂霉素6mg/m2静注第1天。UFTM方案:丝裂霉素20mg,静注,每周一次,连用三周,从治疗前第1天起口服优福啶200mg,一日三次,总剂量30g。FAM组18例,UFTM组19例。结果:FAM方案组有效率(CR+PR)为44.4％,有效生存期9.5月;UFTM组有效率(CR+PR)为52.6％,有效生存期10月。两方案的有效率及生存时间无显著性差异(P>0.05)。结论:UFTM组有效率略高于FAM组,毒副反应较后者轻,在门诊或基层医院使用UFTM方案较为适合。
Objective: To compare the efficacy of commonly used chemotherapy regimens for advanced gastric cancer. Methods: 37 patients with advanced gastric cancer treated in our hospital from July 1997 to December 2000 were all confirmed by pathology and/or cytology; FAM: 5-Fu 600 mg/m2. Intravenous. No. 1,8,29 , 36 days; doxorubicin 30mg/m2 intravenous injection, on the 1st and 29th days, mitomycin 6mg/m2 intravenous injection on the first day. UFTM regimen: 20 mg mitomycin, once a week for 3 weeks, from the first day before treatment, 200 mg of unducycline was orally administered three times a day for a total dose of 30 g. There were 18 cases in the FAM group and 19 cases in the UFTM group. Results: The effective rate (CR+PR) of the FAM regimen group was 44.4%, and the effective survival period was 9.5 months. The UFTM group effective rate (CR+PR) was 52.6% and the effective survival period was 10 months. There was no significant difference in the efficiency and survival time of the two schemes (P>0.05). Conclusion: The UFTM group is slightly more effective than the FAM group, and the toxicities are lighter than the latter. It is appropriate to use UFTM in outpatient or primary hospitals.