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矽肺发病机理的研究已有几十年的历史,提出了多种的学说和假说。作者曾于1963年对其中主要的观点作了介绍。多数学者研究了矽尘对机体的作用,而机体对矽尘的反应机理则报道较少。近年来,随着科学技术的发展,对矽肺发病机理的研究逐步深入,并且有了新的发展。现根据我们工作中的体会,结合有关参考文献,提出矽肺发病机理多因素综合作用的设想。矽肺的发生与发展,是在多因素综合作用下以肺疾患为主的复杂的病理变化过程。其中包括矽尘对机体作用和机体对矽尘的反应两个方面。根据其作用程序可分四个阶段。
The pathogenesis of silicosis has been decades of history, put forward a variety of doctrines and hypotheses. The author introduced some of the main ideas in 1963. Most scholars have studied the role of silica dust on the body, while the body of the response mechanism of silica dust is reported less. In recent years, with the development of science and technology, the research on pathogenesis of silicosis has been gradually deepened and new development has been made. Based on the experience of our work, combined with the relevant references, put forward the idea of multiple factors of silicosis pathogenesis. The occurrence and development of silicosis is a complex pathological process characterized mainly by pulmonary diseases under the combined action of multiple factors. Including silica dust on the role of the body and the body’s response to silica dust in two ways. According to its role in the process can be divided into four stages.